T细胞(T cell、T淋巴細胞/T lymphocyte)是淋巴细胞的一种,在免疫反应中扮演着重要的角色。T细胞在胸腺内分化成熟,成熟后移居于周围淋巴组织。随着细胞免疫治疗的日益深入,T细胞的基因工程化改造显得越来越重要。





汉恒原代T细胞专用病毒---- CD4+ T细胞感染实例


   1、Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear;

     (2016年发表于Nature Neuroscience,作者:段树民)

   2、Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury Involvement of PARK2-dependent mitophagy;

     (2016年发表于Autophagy作者:Xiangnan Zhang)

   3、SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain;

     (2016年发表于Nature Communications,作者:陈义汉)

   4、TRB3 links insulin IGF to tumour promotion by interacting with p62 and impeding autophagic proteasomal degradations;

     (2016年发表于Nature Communications,作者:胡卓伟)

   5、Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK;

     (2016年发表于Nature Communications,作者:刘明耀)

   6、POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation;

     (2015年发表于Nature Communications,作者:Yongzhong Liu)

   7、LRP6 acts as a scaffold protein in cardiac gap junction assembly;

     (2016年发表于Nature Communications,作者:陈义汉)

   8、Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression;

     (2016年发表于plos genetics,作者:Jun Yan )

   9、Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy;

     (2016年发表于Kidney International,作者:易凡)

   10、Roles of miR-1-1 and miR-181c in ventricular septal defects;

     (2016年发表于International Journal of Cardiology,作者:Li J)

   11、CCK-8S increased the filopodia and spines density in cultured hippocampal neurons of APP/PS1 and wild-type mice;

     (2013年发表于Neuroscience Letters,作者:王钦文)

   12、Interleukin-1β induces autophagy by affecting calcium homeostasis and trypsinogen activation in pancreatic acinar cells;

     (2013年发表于Int J Clin Exp Pathol ,作者:赵青川)

   13、MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31;

     (2014年发表于Oncology Reports,作者:Chaoyin Jiang)

   14、MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure;

     (2014年发表于Experimental Eye Research,作者: Yingbin Ge)

   15、Suppressor of cytokine signaling (SOCS) 2 attenuates renal lesions in rats with diabetic nephropathy;

     (2014年发表于Acta histochemica,作者: Qiuyue Wang)

   16、construction of recombinant adenovirus vector containing hBMP2 and hVEGF165 genes and its expression in rabbit Bone marrow mesenchymal stem cells;

     (2014年发表于Tissue and Cell,作者:Chun-yang Meng)

   17、Ulinastatin Reduces the Resistance of Liver Cancer Cells to Epirubicin by Inhibiting Autophagy;

     (2014年发表于plos one,作者:金钢、胡先贵)

   18、MicroRNA-204-5p–Mediated Regulation of SIRT1 Contributes to the Delay of Epithelial Cell Cycle Traversal in Diabetic Corneas;


   19、Adenovirus siMDM2 and NDRG2 Gene Therapy Inhibits Cell Proliferation and Induces Apoptosis of Squamous Cell Carcinoma;

     (2015年发表于Cell Biochemistry and Biophysics,作者:Li Zhang)

   20、The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species;

     (2015年发表于Oxidative Medicine and Cellular Longevity,作者:Xin Shen)

   21、Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro;

     (2015年发表于International Journal of Molecular Medicine,作者:Yong Wang)

   22、SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting ;

     (2015年发表于Journal of Pharmacological Sciences,作者:刘培庆)

   23、Effects of insulin-like growth factor-1 on the assembly and secretion of very low-density lipoproteins in cow hepatocytes in vitro;

     (2015年发表于General and Comparative Endocrinology,作者:刘国文)

   24、SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy;

     (2015年发表于Translational Research,作者:刘培庆)

   25、Transcription factor E2-2 inhibits the proliferation of endothelial progenitor cells by suppressing autophagy;

     (2016年发表于International Journal of Molecular Medicine,作者:Hong Wang)

   26、Effect of adenovirus-mediated RNA interference of IL-1β expression on spinal cord injury in rats;

     (2016年发表于Spinal Cord)

   27、miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2;

     (2016年发表于Cell Death and Disease,作者: Q Zhao)

   28、Adipose-derived stem cells induce autophagic activation and inhibit catabolic response to pro-inflammatory cytokines in rat chondrocytes;

     (2016年发表于Osteoarthritis and Cartilage,作者: Jian Zhang)

   29、β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy;

     (2016年发表于 Cell Death and Disease,作者:F Yi )

   30、MicroRNA-30a downregulation contributes to chemoresistance of osteosarcoma cells through activating Beclin-1-mediated autophagy;

     (2016年发表于Oncology Reports,作者:Lifeng Lao)

   31、Luteolin alleviates post‐infarction cardiac dysfunction by up‐regulating autophagy through Mst1 inhibition;

     (2016年发表于J. Cell. Mol. Med.,作者:Dongdong Sun )

   32、Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p;

     (2016年发表于Biochemical and Biophysical Research Communications,作者: Jiahong Dong)

   33、Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway;

     (2015年发表于Tumor Biology,作者:Xinchen Sun)

   34、Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p;

     (发表于Biochemical and Biophysical Research Communications,作者:Jiahong Dong)

   35、miR-186 inhibits cell proliferation in multiple myeloma by repressing Jagged1;

     (2016年发表于Biochemical and Biophysical Research Communications,作者:Jun Peng)

   36、House dust mite extract induces growth factor expression in nasal mucosa by activating the PI3K/Akt/HIF-1α pathway;

     (2016年发表于Biochem Biophys Res Commun,作者:Zhou H)

   37、构建大鼠白细胞介素1β 基因shRNA 腺病毒载体;

     (2015年发表于中国组织工程研究 )

   38、Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1;

     (2016年发表于Oncotarget,作者:Heng Ma)

   39、A novel role of microRNA 17-5p in the modulation of circadian rhythm;

     (2016年发表于Sci Rep,作者:Ji-Min Cao )

   40、Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease;

     (2016年发表于J Autoimmun,作者:Xiao Y)

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